Glutathione

The body's master antioxidant tripeptide (Gly-Cys-Glu). Detoxifies free radicals, supports liver function and cellular repair.

Route: IM/SubQShelf life once mixed: ~30 daysCategory: Longevity

What Glutathione is

Glutathione is a ubiquitous tripeptide, gamma-L-glutamyl-L-cysteinylglycine, found in nearly all mammalian cells, where it functions as a primary endogenous antioxidant. Rather than targeting specific receptors, it exerts its effects through direct chemical reactions and as a crucial cofactor for numerous enzymes, including glutathione S-transferases (GSTs) and glutathione peroxidases (GPx). The key to its biochemical activity lies in the thiol group of its cysteine residue, which allows it to participate in redox cycling, directly neutralize reactive oxygen species and electrophilic compounds, and regenerate other antioxidants like vitamins C and E. While its intracellular half-life can be relatively short, often ranging from minutes to a few hours depending on the tissue, cellular levels are continuously maintained through robust synthesis and recycling pathways. This tripeptide plays a fundamental role in detoxifying xenobiotics, maintaining cellular redox balance, and supporting immune function.

In a research context, the practical use of glutathione typically focuses on supporting overall cellular health, detoxification, and mitigating oxidative stress. Observable effects, if any, may develop subtly over weeks to months of consistent use rather than presenting acutely. Due to documented challenges with the oral bioavailability of reduced glutathione, researchers often investigate liposomal or sublingual formulations, or explore the use of precursors such as N-acetylcysteine (NAC) to enhance endogenous synthesis. It is commonly explored in combination with compounds that help regenerate its reduced form, such as Vitamin C, or provide synergistic antioxidant support, like alpha-lipoic acid or selenium. Given its foundational role in cellular protection, ongoing use for extended periods is frequently considered, rather than distinct cycling periods. Any investigation into the use of glutathione is for research purposes only.

Commonly reported effects

Antioxidant defense
Liver detox support
Skin brightening
Cellular repair

Reported side effects & considerations

Sulfur-like odor after injection
Rare temporary skin lightening

Storage & handling

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

AFTER RECONSTITUTION: refrigerate 2-8°C. Do NOT freeze. Discard after 30 days OR if the solution becomes cloudy, discolored, or contains particulates.

What people track

Because individual responses vary so much, the useful thing is your own record: what you logged and when, how much is left in the vial, and how your chosen metrics move over the weeks. Peptide Wizard keeps all of that in one place, alongside a 3D reference vial for Glutathione.

FAQ

What is Glutathione?

The body's master antioxidant tripeptide (Gly-Cys-Glu). Detoxifies free radicals, supports liver function and cellular repair.

What do people commonly report with Glutathione?

Commonly reported effects include antioxidant defense, liver detox support, skin brightening, cellular repair.

How should Glutathione be stored?

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

How do I keep track of Glutathione in my research log?

Peptide Wizard lets you record each entry, keep a vial ledger so you know what's left, and chart your own metrics over time. It is a logbook and reference only — it does not calculate or recommend doses.