Longevity

Humanin

Mitochondrial-derived peptide with neuroprotective and metabolic benefits.

Route: SubQShelf life once mixed: ~30 daysCategory: Longevity

What Humanin is

Humanin is a naturally occurring mitochondrial-derived peptide, produced from a short open reading frame within the mitochondrial genome. It is understood to exert its biological effects through interactions with various cellular components, notably by binding to certain cell surface receptors such as components of the ciliary neurotrophic factor (CNTF) receptor complex, including CNTFRα, gp130, and LIFRβ. Furthermore, it is reported to interact with insulin-like growth factor binding protein 3 (IGFBP-3), thereby influencing downstream signaling pathways. These interactions are thought to contribute to its observed roles in inhibiting apoptosis, reducing oxidative stress, and supporting mitochondrial health, although a precise systemic half-life is not widely characterized in human physiological contexts.

In research contexts, the observable effects of Humanin are generally considered to be gradual and cumulative rather than immediate, often requiring consistent administration over weeks or months to investigate potential neuroprotective or metabolic benefits. Due to its multifaceted actions on cellular health, researchers may explore its use in conjunction with other agents aimed at supporting mitochondrial function or cellular resilience, though established "stacks" are not defined. It is important to remember that Humanin is a research peptide and its use is strictly for scientific investigation, not for human consumption or medical treatment.

Commonly reported effects

Neuroprotection
Insulin sensitivity
Longevity markers

Reported side effects & considerations

Minimal reported

Storage & handling

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

AFTER RECONSTITUTION: refrigerate 2-8°C. Do NOT freeze. Discard after 30 days OR if the solution becomes cloudy, discolored, or contains particulates.

What people track

Because individual responses vary so much, the useful thing is your own record: what you logged and when, how much is left in the vial, and how your chosen metrics move over the weeks. Peptide Wizard keeps all of that in one place, alongside a 3D reference vial for Humanin.

FAQ

What is Humanin?

Mitochondrial-derived peptide with neuroprotective and metabolic benefits.

What do people commonly report with Humanin?

Commonly reported effects include neuroprotection, insulin sensitivity, longevity markers.

How should Humanin be stored?

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

How do I keep track of Humanin in my research log?

Peptide Wizard lets you record each entry, keep a vial ledger so you know what's left, and chart your own metrics over time. It is a logbook and reference only — it does not calculate or recommend doses.