Goralatide (Ac-SDKP)

Natural tetrapeptide from thymosin-β4. Regulates hematopoietic stem cell entry and has anti-fibrotic effects.

Route: SubQShelf life once mixed: ~30 daysCategory: Longevity

What Goralatide (Ac-SDKP) is

Goralatide, also known as Ac-SDKP, is a naturally occurring tetrapeptide derived from thymosin-beta 4, an endogenous actin-sequestering protein. This peptide primarily acts as an endogenous regulator of hematopoietic stem cell (HSC) proliferation, inhibiting their entry into the S-phase of the cell cycle and thus promoting a quiescent state. Beyond its role in stem cell biology, Ac-SDKP is recognized for its anti-fibrotic effects, largely through its modulation of the transforming growth factor-beta 1 (TGF-β1) signaling pathway, which is a key mediator of fibrosis in various tissues. Its biochemical action involves influencing gene expression related to extracellular matrix deposition. The peptide has a relatively short half-life in circulation, as it is readily degraded by enzymes such as angiotensin-converting enzyme (ACE) and other peptidases.

In a research context, Goralatide (Ac-SDKP) is investigated for its potential to mitigate fibrotic conditions and its effects on stem cell dynamics. The timeline for observing effects in research models can vary, with anti-fibrotic benefits potentially becoming apparent over several weeks to months, depending on the specific model and study design. Given its interaction with the TGF-β1 pathway, it is sometimes studied in combination with other agents that modulate fibrotic processes or immune responses. A notable consideration for researchers is the peptide's susceptibility to degradation by ACE, which has led to studies exploring co-administration with ACE inhibitors to prolong its systemic availability. It is important to emphasize that Goralatide (Ac-SDKP) is a research chemical for investigational use only and is not intended for human therapeutic application or as medical advice.

Commonly reported effects

Anti-fibrotic (cardiac, renal, pulmonary)
Hematopoietic modulation
Anti-inflammatory

Reported side effects & considerations

Rare mild fatigue

Storage & handling

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

AFTER RECONSTITUTION: refrigerate 2-8°C. Do NOT freeze. Discard after 30 days OR if the solution becomes cloudy, discolored, or contains particulates.

What people track

Because individual responses vary so much, the useful thing is your own record: what you logged and when, how much is left in the vial, and how your chosen metrics move over the weeks. Peptide Wizard keeps all of that in one place, alongside a 3D reference vial for Goralatide (Ac-SDKP).

FAQ

What is Goralatide (Ac-SDKP)?

Natural tetrapeptide from thymosin-β4. Regulates hematopoietic stem cell entry and has anti-fibrotic effects.

What do people commonly report with Goralatide (Ac-SDKP)?

Commonly reported effects include anti-fibrotic (cardiac, renal, pulmonary), hematopoietic modulation, anti-inflammatory.

How should Goralatide (Ac-SDKP) be stored?

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

How do I keep track of Goralatide (Ac-SDKP) in my research log?

Peptide Wizard lets you record each entry, keep a vial ledger so you know what's left, and chart your own metrics over time. It is a logbook and reference only — it does not calculate or recommend doses.