MK-677 (Ibutamoren)

Oral, non-peptide ghrelin agonist. Elevates GH and IGF-1 24/7. Included for stack tracking.

Route: OralShelf life once mixed: ~60 daysCategory: Growth Hormone

What MK-677 (Ibutamoren) is

MK-677, also known as Ibutamoren, functions as a non-peptide ghrelin receptor agonist, specifically targeting the growth hormone secretagogue receptor type 1a (GHSR-1a). By mimicking the action of endogenous ghrelin, it stimulates the pituitary gland to increase the pulsatile secretion of growth hormone (GH). This mechanism leads to sustained elevations of both GH and insulin-like growth factor 1 (IGF-1) levels in the body, typically over a 24-hour period due to its approximate 24-hour half-life. It operates by enhancing the signaling pathways that regulate GH release without directly affecting cortisol levels.

In research settings, MK-677 is typically studied for its potential effects over several weeks to months, as the physiological changes associated with elevated GH and IGF-1 levels, such as alterations in body composition or sleep quality, may manifest gradually. It is sometimes explored in conjunction with other research compounds that target muscle protein synthesis or fat metabolism. Research protocols often involve administration periods ranging from several weeks to several months due to its chronic impact on hormone levels. Notable considerations in research include potential increases in appetite and a need to monitor glucose metabolism, as it may affect insulin sensitivity in some subjects; some researchers also report observations of lethargy or mild fluid retention. This compound is intended for research purposes only and is not approved for therapeutic use in humans.

Commonly reported effects

Sustained GH/IGF-1 elevation
Appetite increase
Deeper sleep

Reported side effects & considerations

Water retention
Lethargy
Insulin resistance

Storage & handling

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

AFTER RECONSTITUTION: refrigerate 2-8°C. Do NOT freeze. Discard after 60 days OR if the solution becomes cloudy, discolored, or contains particulates.

What people track

Because individual responses vary so much, the useful thing is your own record: what you logged and when, how much is left in the vial, and how your chosen metrics move over the weeks. Peptide Wizard keeps all of that in one place, alongside a 3D reference vial for MK-677 (Ibutamoren).

FAQ

What is MK-677 (Ibutamoren)?

Oral, non-peptide ghrelin agonist. Elevates GH and IGF-1 24/7. Included for stack tracking.

What do people commonly report with MK-677 (Ibutamoren)?

Commonly reported effects include sustained gh/igf-1 elevation, appetite increase, deeper sleep.

How should MK-677 (Ibutamoren) be stored?

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

How do I keep track of MK-677 (Ibutamoren) in my research log?

Peptide Wizard lets you record each entry, keep a vial ledger so you know what's left, and chart your own metrics over time. It is a logbook and reference only — it does not calculate or recommend doses.