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MK-677 (Ibutamoren) vs CJC-1295 (no DAC)
MK-677 (Ibutamoren) and CJC-1295 (no DAC) are both growth hormone peptides, which is why they get recommended interchangeably — but they are different compounds with different origins. A mixed vial also keeps differently: about 60 days for MK-677 (Ibutamoren) against 30 for CJC-1295 (no DAC). The table below sets out the differences. We give no dosing guidance.
Side by side, in plain English — what each one is, where they overlap and where they genuinely differ.
MK-677 (Ibutamoren)Growth Hormone
CJC-1295 (no DAC)Growth HormoneAt a glance
| MK-677 (Ibutamoren) | CJC-1295 (no DAC) | |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Typical route | Oral | SubQ |
| Shelf life once mixed | ~60 days | ~30 days |
| Commonly reported effects | Sustained GH/IGF-1 elevation Appetite increase Deeper sleep | Enhanced GH pulse Improved recovery Better sleep Anti-aging |
| Reported considerations | Water retention Lethargy Insulin resistance | Flushing Injection site redness |
The differences that actually matter
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Route of administration differs — MK-677 (Ibutamoren) is typically oral, CJC-1295 (no DAC) is typically subq. That alone changes how convenient each one is to keep up with.
Once reconstituted, MK-677 (Ibutamoren) keeps noticeably longer than CJC-1295 (no DAC) (~60 days vs ~30 days), so vial waste is a real difference between the two.
Where they overlap: deeper sleep.
Reported mainly for MK-677 (Ibutamoren): sustained gh/igf-1 elevation, appetite increase.
Reported mainly for CJC-1295 (no DAC): enhanced gh pulse, improved recovery, anti-aging.
What MK-677 (Ibutamoren) is
MK-677, also known as Ibutamoren, functions as a non-peptide ghrelin receptor agonist, specifically targeting the growth hormone secretagogue receptor type 1a (GHSR-1a). By mimicking the action of endogenous ghrelin, it stimulates the pituitary gland to increase the pulsatile secretion of growth hormone (GH). This mechanism leads to sustained elevations of both GH and insulin-like growth factor 1 (IGF-1) levels in the body, typically over a 24-hour period due to its approximate 24-hour half-life. It operates by enh
What CJC-1295 (no DAC) is
CJC-1295 (no DAC) is a synthetic analog of Growth Hormone Releasing Hormone (GHRH), a naturally occurring peptide produced by the hypothalamus. This research peptide functions by selectively binding to and activating the Growth Hormone Releasing Hormone Receptor (GHRH-R), which is primarily located on somatotroph cells within the anterior pituitary gland. Activation of these receptors stimulates the pituitary to synthesize and secrete endogenous Growth Hormone (GH) into the bloodstream. Due to its relatively short
How to compare them for yourself
Anecdotes online are noisy because nobody is measuring the same thing. The only comparison that means anything is your own: log each entry with a timestamp, keep the vial ledger honest so you know what you actually got through, pick two or three metrics before you start, and look at the trend after several weeks rather than day to day.
Peptide Wizard does that part for you — MK-677 (Ibutamoren) and CJC-1295 (no DAC) are both in the built-in reference library with a 3D vial, and your history, vial ledger and cost per entry stay private on your device.
FAQ
What is the difference between MK-677 (Ibutamoren) and CJC-1295 (no DAC)?
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Can you log MK-677 (Ibutamoren) and CJC-1295 (no DAC) in the same period?
Plenty of people record more than one peptide at a time. Peptide Wizard keeps a separate vial ledger and entry history for each, so you can see exactly what overlapped and when — it does not recommend combinations or doses.
Which is better, MK-677 (Ibutamoren) or CJC-1295 (no DAC)?
There isn't a universal answer — reported responses vary a lot between individuals, which is why your own log is more informative than anyone else's anecdote. Track one variable at a time and compare your own metrics over several weeks.
Is this medical advice?
No. This page is educational reference material only. It contains no dosing guidance. Speak to a qualified healthcare professional before making any decisions.
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Educational reference only. This page contains no dosing guidance and is not medical advice.