Immune

LL-37

Cathelicidin antimicrobial peptide. Anti-bacterial, anti-viral, and immune modulating.

Route: SubQShelf life once mixed: ~30 daysCategory: Immune

What LL-37 is

LL-37 is a human cathelicidin antimicrobial peptide, a component of the innate immune system. Its mechanism of action involves direct disruption of microbial membranes, providing broad-spectrum antibacterial and antiviral activity. Beyond this direct action, LL-37 acts as a signaling molecule, interacting with various cellular receptors, including G-protein coupled receptors like FPR2, to modulate immune responses. This interaction can influence processes such as chemotaxis, angiogenesis, and cytokine production. Biochemically, LL-37 is an amphipathic alpha-helical peptide, allowing it to insert into and destabilize membranes. While its systemic half-life in circulation can be relatively short, often minutes to hours, its downstream signaling effects and accumulation at sites of inflammation can prolong its biological impact.

In research settings, LL-37 is explored for its potential in modulating immune responses and host defense. Expected effects and their timeline are highly dependent on the specific research question, but antimicrobial activities might be observed relatively quickly, while immunomodulatory effects could unfold over days or weeks. Due to its multifaceted nature, researchers may investigate its use in combination with other agents to explore synergistic effects in various immune-related models. Research protocols dictate cycle lengths, which vary significantly based on experimental design. It is important to remember that LL-37 is a research peptide and not intended for medical use.

Commonly reported effects

Broad antimicrobial
Wound healing
Immune boost

Reported side effects & considerations

Injection site irritation

Storage & handling

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

AFTER RECONSTITUTION: refrigerate 2-8°C. Do NOT freeze. Discard after 30 days OR if the solution becomes cloudy, discolored, or contains particulates.

What people track

Because individual responses vary so much, the useful thing is your own record: what you logged and when, how much is left in the vial, and how your chosen metrics move over the weeks. Peptide Wizard keeps all of that in one place, alongside a 3D reference vial for LL-37.

FAQ

What is LL-37?

Cathelicidin antimicrobial peptide. Anti-bacterial, anti-viral, and immune modulating.

What do people commonly report with LL-37?

Commonly reported effects include broad antimicrobial, wound healing, immune boost.

How should LL-37 be stored?

LYOPHILIZED (unopened): store at 2-8°C (fridge) or -20°C (freezer) long-term. Protect from light.

How do I keep track of LL-37 in my research log?

Peptide Wizard lets you record each entry, keep a vial ledger so you know what's left, and chart your own metrics over time. It is a logbook and reference only — it does not calculate or recommend doses.