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Cagrilintide + Semaglutide (CagriSema)

An amylin analogue pre-mixed with a GLP-1 receptor agonist, referred to as CagriSema. Sold as a single vial with the two strengths printed as a pair.

Short answer

Cagrilintide + Semaglutide (CagriSema) is a blends peptide. An amylin analogue pre-mixed with a GLP-1 receptor agonist, referred to as CagriSema. Sold as a single vial with the two strengths printed as a pair. This page covers what it is, how it is stored and how to keep your own records — it does not recommend doses.

Route: SubQCategory: Blends

What Cagrilintide + Semaglutide (CagriSema) is

Cagrilintide + Semaglutide is a blend designed to target two distinct but complementary metabolic pathways. Cagrilintide functions as an amylin analogue, engaging the amylin receptor, while Semaglutide acts as a glucagon-like peptide-1 (GLP-1) receptor agonist. The amylin analogue slows gastric emptying, suppresses postprandial glucagon secretion, and contributes to satiety signaling. Semaglutide, with its extended half-life of approximately seven days due to albumin binding, enhances glucose-dependent insulin secretion, further suppresses glucagon, and influences appetite regulation through central mechanisms. Cagrilintide also exhibits an extended half-life of around 5-7 days, and the combined effect aims to provide a robust influence on metabolic parameters.

In research settings, the expected effects of Cagrilintide + Semaglutide typically emerge over several weeks, as the long half-lives of both compounds lead to a gradual accumulation and steady state. As a pre-formulated blend, its primary "synergy" is intrinsic, combining the actions of the amylin and GLP-1 pathways. Research protocols often involve administration over extended periods, typically several weeks or months, to assess sustained effects on metabolic markers. Notable considerations include its design as a single-vial product, simplifying the co-administration of these two agents compared to separate preparations. This peptide blend is intended for research use only and should not be considered for personal medical application.

Commonly reported effects

Combined in one vial
Single reconstitution
One shared shelf life

Reported side effects & considerations

As per either compound in the blend
Gastrointestinal effects reported for both compounds

What people track

Because individual responses vary so much, the useful thing is your own record: what you logged and when, how much is left in the vial, and how your chosen metrics move over the weeks. Peptide Wizard keeps all of that in one place, alongside a 3D reference vial for Cagrilintide + Semaglutide (CagriSema).

FAQ

What is Cagrilintide + Semaglutide (CagriSema)?

An amylin analogue pre-mixed with a GLP-1 receptor agonist, referred to as CagriSema. Sold as a single vial with the two strengths printed as a pair.

Is Cagrilintide + Semaglutide (CagriSema) a peptide?

Yes — Cagrilintide + Semaglutide (CagriSema) is a peptide, meaning a short chain of amino acids. Peptides are usually handled as a freeze-dried powder that is mixed with bacteriostatic water before use.

Is Cagrilintide + Semaglutide (CagriSema) a steroid?

No. Cagrilintide + Semaglutide (CagriSema) is not an anabolic steroid. Steroids are fat-soluble hormones built on a four-ring cholesterol backbone; peptides are chains of amino acids and work by signalling to receptors rather than acting directly on DNA in the same way.

What do people commonly report with Cagrilintide + Semaglutide (CagriSema)?

Commonly reported effects include combined in one vial, single reconstitution, one shared shelf life.

How should Cagrilintide + Semaglutide (CagriSema) be stored?

Store as directed by the supplier, protected from light and heat.

How do I keep track of Cagrilintide + Semaglutide (CagriSema) in my research log?

Peptide Wizard lets you record each entry, keep a vial ledger so you know what's left, and chart your own metrics over time. It is a logbook and reference only — it does not calculate or recommend doses.

How long does Cagrilintide + Semaglutide (CagriSema) last once it is mixed?

As a general convention a reconstituted vial is treated as good for around 28 days refrigerated at 2-8 C, roughly 60 days frozen, and only a few days at room temperature. That figure comes from standard practice for preserved multi-dose vials rather than a test on any single compound, so the instructions supplied with your own vial take precedence. There is a full storage guide at peptidewizard.app/guides/storage/.

Is Cagrilintide + Semaglutide (CagriSema) taken orally or by injection?

Cagrilintide + Semaglutide (CagriSema) is generally handled as subq. Sealed powder is normally kept refrigerated or frozen and mixed with bacteriostatic water when it is going to be used.

What is the difference between Cagrilintide + Semaglutide (CagriSema) and a steroid or a hormone drug?

Cagrilintide + Semaglutide (CagriSema) is a chain of amino acids that signals to receptors. Anabolic steroids are fat-soluble hormones built on a cholesterol backbone and behave completely differently in the body. Neither this page nor the app provides guidance on using either.

How much does Cagrilintide + Semaglutide (CagriSema) cost per dose?

Divide what you paid for the vial by the number of doses in it. A 10 mg vial contains 10 mg, or 10000 mcg, so the number of doses depends entirely on the amount you use. The calculator on this page does the arithmetic, including the doses you lose if the vial expires first.

Is a bigger Cagrilintide + Semaglutide (CagriSema) vial cheaper?

Per milligram, usually yes. Per dose you actually use, not always — a larger vial you cannot finish inside its stability window can work out more expensive than a smaller one you do finish, because the leftover doses were still paid for.

Why is my real cost higher than price divided by doses?

Because a reconstituted vial has a limited usable window, commonly quoted as around 28 days refrigerated. Doses still in the vial when that window closes are wasted, so the honest figure is the price divided by the doses you reach in time.

How long does Cagrilintide + Semaglutide (CagriSema) last once mixed?

Commonly quoted at around 28 days when kept refrigerated. Frozen extends that considerably, provided you freeze it once rather than thawing and refreezing. At room temperature you are counting in days. Purity, buffers and preservatives all change the answer, so the information supplied with your own vial takes precedence.

Does Cagrilintide + Semaglutide (CagriSema) need to be refrigerated?

Once reconstituted, refrigeration is the normal recommendation, and heat is by far the biggest cause of degradation. Sealed lyophilized powder is more tolerant but still keeps best cold and away from light.

Can I freeze Cagrilintide + Semaglutide (CagriSema)?

Freezing once is generally considered fine and extends the usable window. Repeated freeze-thaw cycles are what cause damage, so splitting into smaller amounts before freezing means you only thaw what you need.

How do I tell how old my Cagrilintide + Semaglutide (CagriSema) vial is?

Write the date you mixed it on the vial, or record it in a tracking app. Without that date there is no reliable way to know, which is the most common reason a vial gets used past its window or thrown away early.

What a dose of Cagrilintide + Semaglutide (CagriSema) costs

Vials are priced per vial, but you use them per dose. Cagrilintide + Semaglutide (CagriSema) is most commonly sold as a 10 mg presentation. Put in what you paid and the amount you use, and this works out the real figure — including the doses you lose if the vial expires before you finish it. Nothing is stored or sent anywhere.

VIAL PRICE (USD) VIAL SIZE (MG) YOUR DOSE (MCG) DOSES PER WEEK USABLE DAYS ONCE MIXED

—per dose

—doses per vial

—weeks per vial

—per month

Reference arithmetic only. The dose figure is whatever you enter — this site does not suggest one.

A smaller vial sometimes works out cheaper per dose than a larger one, even when the larger one looks better per milligram, because a vial you cannot finish inside its stability window still had to be paid for in full. If the box above shows waste, try a smaller vial size and watch the real figure move.

How long Cagrilintide + Semaglutide (CagriSema) lasts once mixed

The clock starts when you mix it. Reconstituted Cagrilintide + Semaglutide (CagriSema) is generally quoted at around 28 days refrigerated, roughly 60 days frozen if frozen only once, and a few days at room temperature. Sealed powder keeps far longer. Enter the date you mixed it for an exact expiry date.

STATE OF THE VIAL HOW IT IS STORED DATE MIXED

—days remaining

Reference only — purity, buffers and preservatives all change the answer, so the storage information supplied with your own vial takes precedence. Full method and sources in the shelf life reference table.

Four things do the damage, in rough order: heat by a wide margin, then light, then repeated freeze–thaw cycles, then agitation. Swirl a vial to mix it rather than shaking it, and keep it in its box away from light.