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Modified GRF 1-29 vs Sermorelin
Modified GRF 1-29 and Sermorelin are both growth hormone peptides, which is why they get recommended interchangeably — but they are different compounds with different origins. The table below sets out the differences. We give no dosing guidance.
Side by side, in plain English — what each one is, where they overlap and where they genuinely differ.
Modified GRF 1-29Growth Hormone
SermorelinGrowth HormoneAt a glance
| Modified GRF 1-29 | Sermorelin | |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Typical route | SubQ | SubQ |
| Shelf life once mixed | ~30 days | ~30 days |
The differences that actually matter
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
What Modified GRF 1-29 is
Modified GRF 1-29, also known as Mod GRF or CJC-1295 (without DAC), is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH), specifically a modified fragment corresponding to positions 1-29 of the natural GHRH molecule. It targets and binds to the GHRH receptors located on the somatotroph cells in the anterior pituitary gland. This peptide is intended for research purposes only and is not for human medical use.
What Sermorelin is
Sermorelin is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH), specifically mimicking the first 29 amino acids of endogenous GHRH. It is important to note that Sermorelin requires a functional pituitary gland to exert its effects. This peptide is strictly for research purposes and is not approved for human therapeutic use.
How to compare them for yourself
Anecdotes online are noisy because nobody is measuring the same thing. The only comparison that means anything is your own: log each entry with a timestamp, keep the vial ledger honest so you know what you actually got through, pick two or three metrics before you start, and look at the trend after several weeks rather than day to day.
Peptide Wizard does that part for you — Modified GRF 1-29 and Sermorelin are both in the built-in reference library with a 3D vial, and your history, vial ledger and cost per entry stay private on your device.
FAQ
What is the difference between Modified GRF 1-29 and Sermorelin?
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Can you log Modified GRF 1-29 and Sermorelin in the same period?
Plenty of people record more than one peptide at a time. Peptide Wizard keeps a separate vial ledger and entry history for each, so you can see exactly what overlapped and when — it does not recommend combinations or doses.
Which is better, Modified GRF 1-29 or Sermorelin?
There isn't a universal answer — reported responses vary a lot between individuals, which is why your own log is more informative than anyone else's anecdote. Track one variable at a time and compare your own metrics over several weeks.
Is this medical advice?
No. This page is educational reference material only. It contains no dosing guidance. Speak to a qualified healthcare professional before making any decisions.
Handling questions
Whichever you pick, mixing and storage work the same way. Search the guides and land straight on the answer.
Can I shake it? · It went cloudy · Should I filter? · Fridge or freezer?
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Educational reference only. This page contains no dosing guidance and is not medical advice.