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Goralatide (Ac-SDKP) vs TB-500
Goralatide (Ac-SDKP) sits in longevity, while TB-500 sits in healing & recovery — so despite being mentioned together they are used for different things. The table below sets out the differences. We give no dosing guidance.
Side by side, in plain English — what each one is, where they overlap and where they genuinely differ.
Goralatide (Ac-SDKP)Longevity
TB-500Healing & RecoveryAt a glance
| Goralatide (Ac-SDKP) | TB-500 | |
|---|---|---|
| Category | Longevity | Healing & Recovery |
| Typical route | SubQ | SubQ |
| Shelf life once mixed | ~30 days | ~30 days |
| Commonly reported effects | Anti-fibrotic (cardiac, renal, pulmonary) Hematopoietic modulation Anti-inflammatory | Full-body healing Improved flexibility Wound repair Reduced scar tissue |
| Reported considerations | Rare mild fatigue | Head rush Temporary lethargy |
The differences that actually matter
They aren't really substitutes: Goralatide (Ac-SDKP) sits in Longevity while TB-500 sits in Healing & Recovery. People usually pick between them because of a shared secondary effect rather than because they do the same job.
Reported mainly for Goralatide (Ac-SDKP): anti-fibrotic (cardiac, renal, pulmonary), hematopoietic modulation, anti-inflammatory.
Reported mainly for TB-500: full-body healing, improved flexibility, wound repair.
What Goralatide (Ac-SDKP) is
Goralatide, also known as Ac-SDKP, is a naturally occurring tetrapeptide derived from thymosin-beta 4, an endogenous actin-sequestering protein. This peptide primarily acts as an endogenous regulator of hematopoietic stem cell (HSC) proliferation, inhibiting their entry into the S-phase of the cell cycle and thus promoting a quiescent state. Beyond its role in stem cell biology, Ac-SDKP is recognized for its anti-fibrotic effects, largely through its modulation of the transforming growth factor-beta 1 (TGF-β1) sign
What TB-500 is
TB-500 is a synthetic variant of the naturally occurring peptide Thymosin Beta-4 (TB4), a vital component found in virtually all human and animal cells. Its primary mechanism of action centers on its ability to regulate actin, a crucial protein involved in cellular structure, movement, and repair. By interacting with actin, TB-500 promotes cell migration, differentiation, and the formation of new blood vessels, a process known as angiogenesis, which is essential for wound healing. These biochemical activities contr
How to compare them for yourself
Anecdotes online are noisy because nobody is measuring the same thing. The only comparison that means anything is your own: log each entry with a timestamp, keep the vial ledger honest so you know what you actually got through, pick two or three metrics before you start, and look at the trend after several weeks rather than day to day.
Peptide Wizard does that part for you — Goralatide (Ac-SDKP) and TB-500 are both in the built-in reference library with a 3D vial, and your history, vial ledger and cost per entry stay private on your device.
FAQ
What is the difference between Goralatide (Ac-SDKP) and TB-500?
They aren't really substitutes: Goralatide (Ac-SDKP) sits in Longevity while TB-500 sits in Healing & Recovery. People usually pick between them because of a shared secondary effect rather than because they do the same job.
Can you log Goralatide (Ac-SDKP) and TB-500 in the same period?
Plenty of people record more than one peptide at a time. Peptide Wizard keeps a separate vial ledger and entry history for each, so you can see exactly what overlapped and when — it does not recommend combinations or doses.
Which is better, Goralatide (Ac-SDKP) or TB-500?
There isn't a universal answer — reported responses vary a lot between individuals, which is why your own log is more informative than anyone else's anecdote. Track one variable at a time and compare your own metrics over several weeks.
Is this medical advice?
No. This page is educational reference material only. It contains no dosing guidance. Speak to a qualified healthcare professional before making any decisions.
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Educational reference only. This page contains no dosing guidance and is not medical advice.