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Follistatin 344 vs MK-677 (Ibutamoren)
Follistatin 344 and MK-677 (Ibutamoren) are both growth hormone peptides, which is why they get recommended interchangeably — but they are different compounds with different origins. A mixed vial also keeps differently: about 30 days for Follistatin 344 against 60 for MK-677 (Ibutamoren). The table below sets out the differences. We give no dosing guidance.
Side by side, in plain English — what each one is, where they overlap and where they genuinely differ.
Follistatin 344Growth Hormone
MK-677 (Ibutamoren)Growth HormoneAt a glance
| Follistatin 344 | MK-677 (Ibutamoren) | |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Typical route | SubQ (or IM at site) | Oral |
| Shelf life once mixed | ~30 days | ~60 days |
The differences that actually matter
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Route of administration differs — Follistatin 344 is typically subq (or im at site), MK-677 (Ibutamoren) is typically oral. That alone changes how convenient each one is to keep up with.
Once reconstituted, MK-677 (Ibutamoren) keeps noticeably longer than Follistatin 344 (~60 days vs ~30 days), so vial waste is a real difference between the two.
What Follistatin 344 is
Follistatin 344 is a naturally occurring glycoprotein, with this specific isoform being a potent antagonist of myostatin. Follistatin 344 binds directly to myostatin, thereby preventing myostatin from interacting with its receptors on muscle cells and signaling pathways that limit muscle development. Considerations include the method of administration, which can influence localized versus systemic effects, and the ongoing investigation into potential long-term physiological adaptations. It is important to remember
What MK-677 (Ibutamoren) is
MK-677, also known as Ibutamoren, functions as a non-peptide ghrelin receptor agonist, specifically targeting the growth hormone secretagogue receptor type 1a (GHSR-1a). This mechanism leads to sustained elevations of both GH and insulin-like growth factor 1 (IGF-1) levels in the body, typically over a 24-hour period due to its approximate 24-hour half-life. It is sometimes explored in conjunction with other research compounds that target muscle protein synthesis or fat metabolism. This compound is intended for res
How to compare them for yourself
Anecdotes online are noisy because nobody is measuring the same thing. The only comparison that means anything is your own: log each entry with a timestamp, keep the vial ledger honest so you know what you actually got through, pick two or three metrics before you start, and look at the trend after several weeks rather than day to day.
Peptide Wizard does that part for you — Follistatin 344 and MK-677 (Ibutamoren) are both in the built-in reference library with a 3D vial, and your history, vial ledger and cost per entry stay private on your device.
FAQ
What is the difference between Follistatin 344 and MK-677 (Ibutamoren)?
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Can you log Follistatin 344 and MK-677 (Ibutamoren) in the same period?
Plenty of people record more than one peptide at a time. Peptide Wizard keeps a separate vial ledger and entry history for each, so you can see exactly what overlapped and when — it does not recommend combinations or doses.
Which is better, Follistatin 344 or MK-677 (Ibutamoren)?
There isn't a universal answer — reported responses vary a lot between individuals, which is why your own log is more informative than anyone else's anecdote. Track one variable at a time and compare your own metrics over several weeks.
Is this medical advice?
No. This page is educational reference material only. It contains no dosing guidance. Speak to a qualified healthcare professional before making any decisions.
Handling questions
Whichever you pick, mixing and storage work the same way. Search the guides and land straight on the answer.
Can I shake it? · It went cloudy · Should I filter? · Fridge or freezer?
See all peptide comparisons →
Educational reference only. This page contains no dosing guidance and is not medical advice.