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IGF-1 LR3 vs Follistatin 344
IGF-1 LR3 and Follistatin 344 are both growth hormone peptides, which is why they get recommended interchangeably — but they are different compounds with different origins. The table below sets out the differences. We give no dosing guidance.
Side by side, in plain English — what each one is, where they overlap and where they genuinely differ.
IGF-1 LR3Growth Hormone
Follistatin 344Growth HormoneAt a glance
| IGF-1 LR3 | Follistatin 344 | |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Typical route | SubQ | SubQ (or IM at site) |
| Shelf life once mixed | ~30 days | ~30 days |
The differences that actually matter
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Route of administration differs — IGF-1 LR3 is typically subq, Follistatin 344 is typically subq (or im at site). That alone changes how convenient each one is to keep up with.
What IGF-1 LR3 is
It primarily exerts its effects by binding to the IGF-1 receptor, a transmembrane tyrosine kinase receptor, which then initiates intracellular signaling cascades, notably the PI3K/Akt and MAPK pathways, critical for cell growth, proliferation, and differentiation. This decreased binding to IGFBPs allows a greater proportion of IGF-1 LR3 to remain unbound and biologically active for a longer duration, contributing to its prolonged systemic presence and sustained anabolic signaling. It is crucial to remember that IGF
What Follistatin 344 is
Follistatin 344 is a naturally occurring glycoprotein, with this specific isoform being a potent antagonist of myostatin. Follistatin 344 binds directly to myostatin, thereby preventing myostatin from interacting with its receptors on muscle cells and signaling pathways that limit muscle development. Considerations include the method of administration, which can influence localized versus systemic effects, and the ongoing investigation into potential long-term physiological adaptations. It is important to remember
How to compare them for yourself
Anecdotes online are noisy because nobody is measuring the same thing. The only comparison that means anything is your own: log each entry with a timestamp, keep the vial ledger honest so you know what you actually got through, pick two or three metrics before you start, and look at the trend after several weeks rather than day to day.
Peptide Wizard does that part for you — IGF-1 LR3 and Follistatin 344 are both in the built-in reference library with a 3D vial, and your history, vial ledger and cost per entry stay private on your device.
FAQ
What is the difference between IGF-1 LR3 and Follistatin 344?
Both are classed as Growth Hormone peptides, so they get compared constantly and are often researched for overlapping reasons.
Can you log IGF-1 LR3 and Follistatin 344 in the same period?
Plenty of people record more than one peptide at a time. Peptide Wizard keeps a separate vial ledger and entry history for each, so you can see exactly what overlapped and when — it does not recommend combinations or doses.
Which is better, IGF-1 LR3 or Follistatin 344?
There isn't a universal answer — reported responses vary a lot between individuals, which is why your own log is more informative than anyone else's anecdote. Track one variable at a time and compare your own metrics over several weeks.
Is this medical advice?
No. This page is educational reference material only. It contains no dosing guidance. Speak to a qualified healthcare professional before making any decisions.
Handling questions
Whichever you pick, mixing and storage work the same way. Search the guides and land straight on the answer.
Can I shake it? · It went cloudy · Should I filter? · Fridge or freezer?
See all peptide comparisons →
Educational reference only. This page contains no dosing guidance and is not medical advice.